fnctId=prof,fnctNo=167 조영창( Young-Chang Cho) 직위(직급) 학부장 연구실 예방약학연구실 약1-402호 교수전공 및 연구분야 Necroptosis 관련 인산화 효소 활성을 조절하는 탈인산화효소 도출 및 작용기전 규명, 항염 효능 천연물 유래 물질 발굴 및 작용기전 규명, 암세포 선택적 항암 천연물 (선택적 세포사멸 유도) 발굴 및 작용기전 규명 연락처 062-530-2925 이메일 yccho@jnu.ac.kr 홈페이지 - 전공 및 연구분야 본 연구실은 세포 생존에 관여하는 인산화효소를 제어할 수 있는 탈인산화효소를 발굴함으로써 암 조절후보인자로서 도출하고자 하며, 국내외 천연물 및 그 주요 성분들을 이용하여 항염증, 항암 후보물질을 발굴하고 그 작용기전을 규명하는 것을 목표로 한다. 1. Necroptosis 관련 인산화 효소 활성을 조절하는 탈인산화효소 도출 및 작용기전 규명 2. 항염 효능 천연물 유래 물질 발굴 및 작용기전 규명 3. 암세포 선택적 항암 천연물 (선택적 세포사멸 유도) 발굴 및 작용기전 규명 경력 2023.3. – present: Associate Professor 2018 – 2023: Assistant Professor College of Pharmacy, Chonnam National University, Gwang-ju, Korea 2013 – 2018: Research Fellow Department of Pharmacy, Chung-Ang University, Seoul, Korea 2012 – 2013: Post-doctoral fellow (Supervisor: Prof. Sayeon Cho) Department of Pharmacy, Chung-Ang University, Seoul, Korea 2012 – 2012: Post-doctoral fellow (Supervisor: Dr. Sung Goo Park) Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea 학력 2008 – 2012: Ph.D. in Department of Pharmacy (supervisor: Prof. Bok Yun Kang) Chonnam National University, Gwang-ju, Korea 2006 – 2008: M.S. in Department of Pharmacy (supervisor: Prof. Bok Yun Kang) Chonnam National University, Gwang-ju, Korea 2002 – 2006: B.S. in Department of Pharmacy Chonnam National University, Gwang-ju, Korea 주요논문 1. Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages. Le HTT, Cho YC* (co-first author), Cho S. Int J Mol Med 2018 Mar;41(3):1783-1791 2. Dual-specificity phosphatase 5 acts as an anti-inflammatory regulator by inhibiting the ERK and NF-κB signaling pathways. Seo H, Cho YC* (co-first author), Ju A, Lee S, Park BC, Park SG, Kim JH, Kim K, Cho S. Sci Rep 2017 Dec 11;7(1):17348 3. Anticancer effects of methanol extract of Myrmecodia platytyrea Becc. leaves against human hepatocellular carcinoma cells via inhibition of ERK and STAT3 signaling pathways. Ju A, Cho YC, Kim BR, Lee S, Le HTT, Vuong HL, Cho S. Int J Oncol. 2018 Jan;52(1):201-210 4. Anti‑inflammatory effects on murine macrophages of ethanol extracts of Lygodium japonicum spores via inhibition of NF‑κB and p38. Cho YC* (first author), Kim BR, Le HTT, Cho S. Mol Med Rep 2017 Oct;16(4):4362-4370 5. Protein tyrosine phosphatase PTPN21 acts as a negative regulator of ICAM-1 by dephosphorylating IKKβ in TNF-α-stimulated human keratinocytes. Cho YC* (first author), Kim BR, Cho S. BMB Rep 2017 Nov;50(11):584-589 6. Cho YC* (first author), Nguyen TT, Park SY, Kim K, Kim HS, Kim KK, Kim H, Bromopropane compounds increase the stemness of colorectal cancer cells. Int J Mol Sci 2017 1 Sep;18(1):1888 7. Spilanthes acmella inhibits inflammatory responses via inhibition of NF-κB and MAPK signaling pathways in RAW 264.7 macrophages. Cho YC* (first author), Bach TT, Kim BR, Vuong HL, Cho S. Mol Med Rep 2017 July;16(1):339-346 8. Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. Le HTT, Cho YC, Cho S. BMB Rep 2017 Jun;50(6):329-334. 9. Suppression of inflammation by the rhizome of Anemarrhena asphodeloides via regulation of nuclear factor-κB and p38 signal transduction pathways in macrophages. Kim BR*, Cho YC* (co-first author), Le HTT, Vuong HL, Lee S, Cho S. Biomed Rep 2017 Jun;6(6):691-697 10. Thunbergia alata inhibits inflammatory responses through the inactivation of ERK and STAT3 in macrophages. Cho YC* (first author), Kim YR, Kim BR, Bach TT, Cho S. Int J Mol Med 2016 Nov;38(5):1596-1604 11. Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. Ju A, Cho YC, Kim BR, Park SG, Kim JH, Kim K, Lee J, Park BC, Cho S. PLoS One 2016 Oct 6;11(10):e0164259 12. Investigation of the molecular mechanism of δ-catenin ubiquitination: Implication of β-TrCP-1 as a potential E3 ligase. Shrestha H, Yuan T, He Y, Moon PG, Shrestha N, Ryu T, Park SY, Cho YC, Lee CH, Baek MC, Cho S, Simkhada S, Kim H, Kim K. Biochim Biophys Acta 2016 Sep;1863(9):2311-21 13. Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4. Lee SH, Cho YC, Jeong HM, Kim KH, Choi HJ, Lee KY, Kang BY. Arch Pharm Res 2016 Apr;39(4):547-54 14. c-Jun N-terminal kinase-mediated anti-inflammatory effects of Garcinia subelliptica in macrophages. Cho YC* (first author), Cho S. Mol Med Rep 2016 Mar;13(3):2293-300 15. Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling. He Y, Ryu T, Shrestha N, Yuan T, Kim H, Shrestha H, Cho YC, Seo YW, Song WK, Kim K. Sci Rep 2016 Feb 17;6:21207 16. Methanol extracts of Xanthium sibiricum roots inhibit inflammatory responses via the inhibition of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) in murine macrophages. Ju A, Cho YC, Cho S. J Ethnopharmacol 2015 Nov 4;174:74-81 17. Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1. Cho YC* (first author), Park JE, Park BC, Kim JH, Jeong DG, Park SG, Cho S. Cell Death Differ 2015 Oct;22(10):1605-17 (JCR 10% (Biochemistry & Molecular Biology)) 18. Artesunate inhibits proliferation of naïve CD4(+) T cells but enhances function of effector T cells. Lee SH, Cho YC, Kim KH, Lee IS, Choi HJ, Kang BY. Arch Pharm Res 2015 Jun;38(6):1195-203 19. Anti-inflammatory effects of Crataeva nurvala Buch. Ham. are mediated via inactivation of ERK but not NF-κB. Cho YC* (first author), Ju A, Kim BR, Cho S. J Ethnopharmacol 2015 Mar 13;162:140-7 20. Methanol extracts of Euphorbia cooperi inhibit the production of inflammatory mediators by inhibiting the activation of c‑Jun N‑terminal kinase and p38 in murine macrophages. Cho YC* (first author), Lee IS, Seo H, Ju A, Youn D, Kim Y, Choun J, Cho S. Mol Med Rep 2014 Nov;10(5):2663-8