fnctId=prof,fnctNo=167 조남기( Namki Cho) 직위(직급) 부교수 연구실 생약학연구실 약2-301호 교수전공 및 연구분야 국내외 육상식물, 곰팡이류 및 박테리아등으로 부터의 신규 화합물 분리. 치매등의 퇴행성계 뇌 신경계 질환 치료제 개발, 강력한 항암 활성을 갖는 후보물질 발굴 연락처 062-530-2926 이메일 cnamki@jnu.ac.kr 홈페이지 - 전공 및 연구분야 본 연구실은 국내외 천연물로부터 신규 화합물 및 생리활성물질을 분리하고, 이들의 구조를 밝히며 천연의약품 및 건강 기능 식품등을 개발하는 것을 목표로 한다. 1. 국내외 육상식물, 곰팡이류 및 박테리아등으로 부터의 신규 화합물 분리 2. 치매등의 퇴행성계 뇌 신경계 질환 치료제 개발 3. 강력한 항암 활성을 갖는 후보물질 발굴 경력 2014 Postdoctoral Research, College of Pharmacy, Seoul National University 2014-2016 Postdoctoral Fellow, Molecular Targets Laboratory, National Institutes of Health (NIH) 2016-2018 Postdoctoral Associate, Department of Chemistry, Virginia Tech Current Associate professor, Department of Pharmacy, Chonnam National University 학력 2008 Chugnam National University, Pharmacy. B.S. 2014 Seoul National University, Pharmacognosy. Ph.D. 주요논문 1. Cho N, Du Y, Valenciano AL, Fernandez-Murga ML, Goetz M, Clement J, Cassera MB, Kingston DGI. Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud. Bioorg Med Chem Lett. 28(1):40-2 (2018). 2. Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz M, Beutler JA. Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. J Nat Prod. 80(7):2037-44 (2017). 3. Cho N, Kim HW, Kim TB, Ransom TT, Beutler JA, Sung SH. Preparative Purification of Anti-Proliferative Diarylheptanoids from Betula platyphylla by High-Speed Counter-Current Chromatography. Molecules 21(6) (2016). 4. Cho N, Moon EH, Kim HW, Hong J, Beutler JA, Sung SH. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules 21(4) (2016). 5. Cho N, Kim HW, Lee HK, Jeon BJ, Sung SH. Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice. Biosci Biotechnol Biochem. 80(1):166-71 (2016). 6. Kim JW, Yang H, Cho N, Kim B, Kim YC, Sung SH. Hepatoprotective constituents of Firmiana simplex stem bark against ethanol insult to primary rat hepatocytes. Pharmacogn Mag. 11(41):55-60 (2015). 7. Cho N, Yang H, Kim JW, Kim YC, Sung SH. Chemical constituents isolated from Disporum viridescens leaves and their inhibitory effect on nitric oxide production in BV2 microglial cells. Bioorg Med Chem Lett. 24(24):5675-8 (2014). 8. Cho N, Lee HK, Jeon BJ, Kim HW, Kim HP, Lee JH, Kim YC, Sung SH. The effects of Betula platyphylla bark on amyloid beta-induced learning and memory impairment in mice. Food Chem Toxicol. 74:156-63 (2014). 9. Cho N, Yang H, Lee M, Huh J, Kim HW, Kim HP, Sung SH. Neuroprotective benzyl benzoate glycosides from Disporum viridescens roots in HT22 hippocampal neuronal cells. J Nat Prod. 76(12):2291-7 (2013). 10. Cho N, Lee KY, Huh J, Choi JH, Yang H, Jeong EJ, Kim HP, Sung SH. Cognitive enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. Food Chem Toxicol. 58(1):355-61 (2013). 11. Lee KY, Jeong EJ, Huh J, Cho N, Kim TB, Jeon BJ, Kim SH, Kim HP, Sung SH. Cognition-enhancing and neuroprotective activities of the standardized extract of Betula platyphylla bark and its major diarylheptanoids. Phytomedicine. 19(14):1315-20 (2012). 12. Cho N, Choi JH, Yang H, Jeong EJ, Lee KY, Kim YC, Sung SH. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food Chem Toxicol. 50(6):1940-5 (2012). 13. Cho N, Huh J, Yang H, Jeong EJ, Kim YC, Kim J, Sung SH. 2012. Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. J Enzyme Inhib Med Chem. 27(1):1-4 (2012).